Curing heartburn can break your hip
When I was 20 years old, I hurt myself pretty severely. Not just once, but several times. I blame God for this, because for some reason when I was manufactured, the owner’s manual was not included with my model (I’m sure you got yours). So I didn’t know you could not do stupid things, and expect no long lasting ramifications.
As a result, I live with pain on a daily basis. I have learned to live with constant pain, work long hours, and have a happy family— all without becoming an alcoholic or prescription drug junkie. I think I would have made a good spy; I can take pain. So when the KGB started pulling out my fingernails, I would just smile through gritted teeth, tears rolling down my face—- AND TELL THEM ANY DAMN THING THEY WANTED TO KNOW!!
The years of pain pushed me to be in the best physical shape I could be in. I took martial arts, I peddled thousands of miles on my bike, swam hundreds of miles in the pool, lifted weights, ate right, and took a zillion supplements. Initially, I did all this to reduce the pain. By and large, it works. Along the way there have been unfortunate miscalculations (Oh my God, I took 2000 mg instead of 20 mg??!), as well as brilliant revelations (Wow, I can lift a truck!).
I promised I would outline the supplements that I take, why I take them, and what they do. And I’m almost to that point. But for this column, I want to talk about a mistep that brought a revelation.
About 10 years ago, I tried my hand at day trading. I was getting fairly good at it, and was making some nice change on the side. Unfortunately, I don’t have the personality to do this! When you’re shuffling $10k-20K around with only minutes to react, your stress level goes up astronomically. And I developed constant heartburn which evolved into esophageal reflux (GERD). At its worst, it no longer felt like heartburn, but more like someone driving a stake through my chest, as the hydrochloric acid ate little holes in my esophagus. I could easily identify with a vampire’s death at the hands of Buffy.
After months of doctor visits and dreadful tests, and wearing a ph monitor for several days (a wire stuck up your nose and into your belly. Nonstop fun that DeSade would have enjoyed), I was finally put on Prilosec, then ultimately Nexium. And this seemed to control it. The only side effects was muscle cramps (no acid in stomach to absorb minerals and B vitamins), and constipation (poorly digested food in intestines because of no acid). Over time, I could deal with the reflux thanks to Nexium. But, I progressively began to feel “not quite right.” To the point that it would interfere with my bike rides and swimming (muscle cramps).
Then I read an interesting article by Dr. Robert Rowen ( go to http://www.secondopinionnewsletter.com to join). He quoted an article by Dr. Ricardo Pereira that followed 351 patients with heartburn. The study lasted almost 4 years. Patients were given a proton pump inhibitor (omeprazole ) or a supplement cocktail (proton pump inhibitors are drugs like Nexium or Prilosec). After 40 days, 100% of those patients taking the supplement cocktail said their symptoms were gone; whereas only 67.5% of the omeprazole group showed improvement. So as usual, I decided to experiment on myself.
Before I go into the supplement cocktail, let me tell you about proton pump inhibitors. The proton pump (think of them as acid factories) are used throughout your body, not just your stomach; but also in your bones. If you take a drug to shut down the proton pumps, then your stomach and bones no longer use them. Alkaline minerals in your stomach (like calcium, magnesium, zinc, copper, etc.) need acid to be dissolved; suddenly you’re not getting these life essential minerals. In your bones, there are two cells that work constantly to make strong bones; osteoclasts (break down old bone), and osteoblasts (build new bone). Osteoclasts and osteoblasts are constantly tearing down and rebuilding vibrant, strong bone. But, if the osteoclasts can’t tear down the old bone (because proton pumps are shut down), then the osteoblasts deposit new bone on top of old, making bones denser and more brittle.
Dr. Yu-Xiao Yang of the University of Pennsylvania School of Medicine published a study in JAMA that detailed hip fractures in people over 50, compared to a similar group of healthy people. They found that after just 1 year of using proton pump inhibitors (PPI), your risk of hip fracture increased 44%! Long term PPI users’ (taking higher doses) risk of hip fracture increased 260%!!
That’s not good, and I didn’t want any of it. I’ve take care of osteoporotic patients whose spinal bones have collapsed; constant agony and debilitated. Not for me, thanks!
Fortunately I read Dr. Rowen’s article, but also another study (http://www.lef.org/magazine/mag2007/may2007_report_cimetidine_01.htm) about cimetidine. Cimetidine was sold for years as Tagamet, and is used for heartburn relief. It decreases acid production by inhibiting the acid producing cells in the stomach, a different pathway than proton pump inhibitors. A side benefit of cimetidine is that it was discovered to inhibit tumor cell growth and metastasis. That’s for me!
So I took Dr. Pereira’s supplement cocktail for relieving reflux (GERD) and added the cimetidine 200mg at night. My thinking was that I didn’t need acid production in my stomach at night; so no night acid that could splash or ooze into my esophagus when I went to sleep. Putting blocks of wood under the head of my bed to keep my head elevated (so acid wouldn’t run downhill out of my stomach), was now a thing of the past, and unneeded.
Here is Dr. Pereira’s supplement cocktail: melatonin (6 mg daily), L-tryptophan (200 mg daily), vitamin B6 (25 mg daily), folic acid (10 mg daily), vitamin B12 (50 mcg daily), methoinine (100 mg daily), and betaine (100 mg daily) to fight heartburn. I take the melatonin and tryptophan at night because it makes you sleepy. Melatonin inhibits acid production and reduces nitric oxide which relaxes the doorway between your stomach and esophagus (this doorway, sphincter, keeps acid in the stomach).
So what did I learn? Pharmaceuticals are not always blessings. And when we interrupt one process in the body, we fail to consider that we may be disrupting thousands of functions we didn’t know about—until it’s too late.
As for me, my reflux is gone and I haven’t taken a proton pump inhibitor for 2 years.
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